Toll-Like Receptor 2 Regulates Organic Dust–Induced Airway Inflammation
نویسندگان
چکیده
منابع مشابه
Toll-like receptor 2 signalling and inflammation.
T oll-like receptors (TLRs) are a family of proteins that are involved in the initial phase of host defence against invading pathogens. TLRs act as primary sensors of microbial products and activate signalling pathways that lead to the induction of immune and inflammatory genes. TLRs belong to a broader family of proteins, which include receptors for the proinflammatory cytokines interleukin (I...
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Objective(s): To explore whether endoplasmic reticulum (ER) stress regulates inflammation in adipose tissue of obese rats via TLR4 signaling. Materials and Methods: Sprague Dawley rats were randomly divided into four groups, and body weight, food intake, and free fatty acids (FFA) were measured. Real-time PCR and Western blot were used to determine mRNA or protein expression of TLR4, TRAF6, IKK...
متن کاملToll-like receptors and airway inflammation.
The respiratory tract opens to the external environment at the oral side edge, and the other edge of the respiratory tract connects to the closed space (alveoli), and so to preserve the sterility in the terminal respiratory tract is critical for protection against pathogens. The recognition machinery for the invasion of microbes is indispensable for the preservation of the sterility in the lung...
متن کاملDerp2-mutant gene vaccine inhibits airway inflammation and up-regulates Toll-like receptor 9 in an allergic asthmatic mouse model.
BACKGROUND A DNA vaccine encoding the whole segment of the Derp2 allergen could prevent allergic airway inflammation in a Derp2 allergen-induced allergic airway inflammation mouse model. OBJECTIVE This study investigated the effect of DNA vaccine encoding Derp2-mutant gene in which an IgE epitope was deleted on airway inflammation and the role of TLR9 in the asthmatic mouse model. METHODS A...
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Background: Early childhood caries (ECC) is a common health problem in the developing countries. Basic knowledge about the etiology and pathogenesis of ECC plays an important role in its prevention. Objective: To determine the relationship between salivary TLR-2 concentration and early childhood caries formation Methods: Twenty-Eight children with ages ranging from 36 to 71 months (15 in ECC gr...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2011
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2010-0427oc